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              肿瘤免疫治疗性抗体功能鉴定与分析平台

               

              金斯瑞成功开发并验证了靶向不同免疫细胞(NK细胞、T细胞、巨噬细胞)和补体系统的抗体药物活性鉴定与评价方法和技术,包括ADCC、CDC、ADCP、Phagocytosis、T细胞增激活与抑制分析等,涉及的靶点包括CD20、 EGFR、HER2、tm-TNFa、PD-1/PD-L1、CTLA-4、OX-40、TIM-3、 LAG-3、CD40、4-1BB、B7-H3、TIGIT、GITR及CD47等。

              服务内容

                NK细胞
                T细胞
                巨噬细胞
                补体系统
                作用机理
                Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)
                T cell Activation/Inhibition
                Antibody-Dependent Cellular Phagocytosis (ADCP), Phagocytosis
                Complement Dependent Cytotoxicity (CDC)
                已开发的靶点
                CD20, EGFR, HER2, tm-TNFa
                PD-1/PD-L1, CTLA-4,OX-40TIGIT NEWLAG3 NEWGITR NEW4-1BB NEWCD40 NEW
                CD20, HER2, CD47
                CD20, tm-TNFa
                方法学
                PBMC, NK cells, Engineered NK cells,
                IL-2 release
                Mixed-Lymphocyte Reaction (MLR),
                Reporter gene assays
                FACS
                Cell lysis detection

              同时,我们开发了Immuno-Oncology相关靶点过表达稳定细胞株库,主要用于细胞免疫亲和力分析交叉反应及功能分析等。

                Developed Immuno-Oncology Cell Lines
                Target
                Cell Line
                Target
                Cell Line
                4-1BB
                CHO-K1/human 4-1BB
                PD-1
                CHO-K1/human PD-1
                CHO-K1/mouse 4-1BB CHO-K1/mouse PD-1
                CHO-K1/cyno 4-1BB CHO-K1/cyno PD-1
                B7-H3
                CHO-K1/human B7-H3
                PD-L1
                CHO-K1/human PD-L1
                B7-H4
                CHO-K1/human B7-H4 HEK293/human PD-L1
                BTLA
                CHO-K1/human BTLA CHO-K1/mouse PD-L1
                CD160
                CHO-K1/human CD160 CHO-K1/cyno PD-L1
                CD200 R1
                CHO-K1/human CD200 R1
                TIGIT
                CHO-K1/human TIGIT
                CD40
                CHO-K1/human CD40
                Tim3
                CHO-K1/human Tim3
                CD80
                CHO-K1/human CD80
                VISTA
                CHO-K1/human VISTA
                CD86
                CHO-K1/human CD86
                FLT3
                CHO-K1/human FLT3
                CTLA4
                CHO-K1/human CTLA4 CHO-K1/human FLT3 mutant
                CHO-K1/mouse CTLA4 CHO-K1/mouse FLT3
                CHO-K1/cyno CTLA4 CHO-K1/cyno FLT3
                GITR
                CHO-K1/human GITR
                CD38
                CHO-K1/human CD38
                Lag3
                CHO-K1/human Lag3
                CD27
                CHO-K1/human CD27
                OX-40L
                CHO-K1/human OX-40L
                OX-40
                CHO-K1/human OX-40
                mTNFα
                CHO-DG44/mTNFα
                Jurkat/mTNFα

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