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              G蛋白偶联受体是受体蛋白家族中最大的成员之一在细胞信号转导过程中发挥重要生物学功能是最重要的药物靶点。金斯瑞团队历经8年多时间开发了170种以上具有知识产权的GPCR稳定细胞株。这些细胞株均通过功能性和稳定性验证以满足客户的GPCR药物活性筛选与评价需求。

              服务内容

              • 化合物活性筛选与评价(基于钙流cAMP报告基因或IP-1的检测)
              • 化合物与受体间的亲和力分析(基于放射性同位素)
              • 提供GPCR稳定细胞株构建服务或直接出售细胞株产品

              GPCR稳定细胞株

                Family
                Receptor
                Cell Line
                Cat.No.
                5-Hydroxytryptamine receptor 5-HT2A/HTR2A CHO-K1/5-HT2A
                5-HT2B/HTR2B CHO-K1/5-HT2B
                5-HT2B/HTR2B HEK293/5-HT2B
                M00328
                5-HT2C/HTR2C CHO-K1/5-HT2C
                5-HT2C/HTR2C HEK 293/5-HT2C
                HTR4 CHO-K1/5-HT4/Gα15
                HTR7 293/5-HT7/CRE-Luc
                Acetylcholine receptor (muscarinic) M1/CHRM1 CHO-K1/M1
                M2/CHRM2 CHO-K1/M2/Gα15
                M3/CHRM3 CHO-K1/M3
                M4/CHRM4 CHO-K1/M4/Gα15
                M5/CHRM5 CHO-K1/M5
                Adenosine receptor ADORA1 CHO-K1/ADORA1/Gα15
                ADORA1 293/ADORA1/Gα15
                ADORA2a CHO-K1/ADORA2A/Gα15
                Mouse ADORA2a CHO-K1/mouse ADORA2a New
                M00575
                ADORA2B CHO-K1/ADORA2B/Gα15
                ADORA3 CHO-K1/ADORA3/Gqi5
                Adrenoceptors ADRA1B CHO-K1/ADRA1B
                ADRA1D CHO-K1/ADRA1D
                ADRA2A CHO-K1/ADRA2A/Gα15
                ADRA2B CHO-K1/ADRA2B/Gqi5
                ADRA2C CHO-K1/ADRA2C/Gα15
                ADRA1 CHO-K1/ADRA1/Gα15
                ADRB2 CHO-K1/Ga15/ADRB2
                ADRA1A CHO-K1/ADRA1A
                Angiotensin receptor AT1 HEK 293/AT1
                AT1 293T/AT1
                Apelin receptor AGTRL1 CHO-K1/AGTRL1/Gα15
                Bile acid receptor GPBAR1 CHO-K1/GPBAR1SatbleCellLine

              返回顶部

                Family
                Receptor
                Cell Line
                Cat.No.
                Bombesin receptor BB1 CHO-K1/BB1
                BB2/GRPR CHO-K1/BB2
                BB3/BRS3 CHO-K1/BB3
                Bradykinin receptor B2 CHO-K1/B2/Gα15
                Calcitonin receptor AMY1 CHO-K1/Gα15/AMY1 New
                AMY2 CHO-K1/Gα15/AMY2 New
                AMY3 CHO-K1/Gα15/AMY3 New
                RAMP2/CALCRL CHO-K1/RAMP2
                M00450
                RAMP3/CALCRL CHO-K1/Ga15/RAMP3
                M00479
                CALCR/CT CHO-K1/CT/Gα15
                Cannabinoid receptor CNR1/CB1 CHO-K1/CB1/Gα15
                CB2 CHO-K1/CB2
                Chemerin receptor CMKLR1 CHO-K1/CMKLR1/Gα15
                Chemokine receptor CCR1 CHO-K1/Gα15/CCR1 New
                CCR5 CHO-K1/Gα15/CCR5 New
                CXCR1/IL8RA CHO-K1/Gα15/CXCR1 New
                CXCR3 CHO-K1/Gα15/CXCR3 New
                CXCR4 CHO-K1/Gα15/hCXCR4 New
                CXCR5/BLR1 CHO-K1/Gα15/CXCR5 New
                Cholecystokinin receptor CCKA/CCKAR CHO-K1/CCKA/Gα15
                CCKB/CCKBR CHO-K1/CCKB
                Class A orphan GPR68/OGR1 CHO-K1/GPR68/Gα15
                GPR119 CHO-K1/GPR119
                M00499
                GPR68/OGR1 CHO-K1/Ga15/GPR68
                MRGPRD/MRGD CHO-K1/Ga15/MRGPRD
                M00467
                MRGPRX1 CHO-K1/Ga15/MRGPRX1
                M00484
                MRGPRX1 CHO-K1
                M00425
                Complement peptide receptor C5a/C5AR1 CHO-K1/C5a/Gα15
                Corticotropin releasing factor receptor CRF1/CRHR1 CHO-K1/CRF1/Gα15
                CRF2 CHO-K1/CRF2/Gα15
                Dopamine receptor D2 CHO-K1/D2/Gα15
                D1/DRD1 CHO-K1/D1
                M00247
                D2(Short) CHO-K1/D2s/Gα15
                DRD4 293 c18/DRD4
                M00477
                Endothelin receptor ETA/EDNRA CHO-K1/EDNRA
                ETB/EDNRB CHO-K1/EDNRB
                Formylpeptide receptor FPR1 CHO-K1/FPR1/Gα15
                Free fatty acid receptor FFA2 CHO-K1/FFA2/Gα15
                GPR40/FFA1 CHO-K1/FFA1/Gα15

              返回顶部

                Family
                Receptor
                Cell Line
                Cat.No.
                Galanin receptor GAL1/GALR1 CHO-K1/GAL1/Gα15
                GAL2/GALR2 CHO-K1/GAL2
                Glucagon receptor GHRHR 293/GHRH/Gα15
                GLP-1/GLP1R CHO-K1/GLP1/Gα15
                GLP-1/GLP1R HEK293/CRE-luc/GLP1R New
                M00562
                GLP-2/GLP2R CHO-K1/GLP2/Gα15
                GCGR CHO-K1/GCGR/Gα15
                GCGR HEK 293/GCGR/Gα15
                SCTR CHO-K1/SCTR/Gα15
                GIPR CHO-K1/GIPR/Gα15
                Gonadotropin releasing hormone receptor GNRHR CHO-K1/GNRHR/Gα15
                Growth hormone releasing peptides receptor GHSR CHO-K1/GHSR
                Histamine receptor H1/HRH1 293/H1
                H2/HRH2 CHO-K1/H2/Gα15
                H3/HRH3 CHO-K1/H3/Gα15
                H4/HRH4 CHO-K1/H4/Gα15
                Hydroxycarboxlic acid receptor GPR109A CHO-K1/NIACR1/Gα15
                Kisspeptin receptor KiSS1/GPR54 CHO-K1/KiSS1
                Leukotriene receptor OXER1/flag CHO-K1/Gα15/OXER1
                M00488
                LTB4R CHO-K1/LTB4/Gα15
                Lysophospholipid receptor EDG3 RH7777/EDG3
                M00476
                CEDG1 CHO-K1/Gα15/EDG1
                M00574
                EDG6/S1P4 McA-RH7777/EDG6
                M00465
                P2Y5/LAPR6 McA-RH7777/P2Y5
                M00472
                EDG4/LAP2 RH7777/EDG4
                Melanin concentrating hormone receptor MCH1/GPR24 293/MCH1
                MCH2/GPR145 CHO-K1/MCH2
                Melanocortin receptor MC1 CHO-K1/MC1
                M00240
                MC2 CHO-K1/MC2/Gα15
                MC3 CHO-K1/MC3/Gα15
                MC3 293/MC3/CRE-Luc
                MC4 CHO-K1/MC4/Gα15
                MC5 CHO-K1/MC5/Gα15
                Melatonin receptor MTNR1A CHO-K1/MT1/Gα15
                MT2/MTNR1B CHO-K1/MT2/Gα15
                Metabropic glutamate receptor mGlu2/GRM2 CHO-K1/GRM2/Gα15
                Motilin receptor MTLR/MLNR CHO-K1/MTLR/Gα15

              返回顶部

                Family
                Receptor
                Cell Line
                Cat.No.
                Neuromedin receptor NMU1/GPR66 CHO-K1/NMU1
                Neuropeptide S receptor NPSR1 CHO-K1/NPS1a/Gα15
                Neuropeptide Y receptor NPY2 CHO-K1/NPY2/Gqi5
                NPY4R CHO-K1/NPY4/Gα15
                Neurotensin receptor NTS1/NT1 CHO-K1/NTS1
                Neuropeptide FF/neuropeptide AF receptors NPFFR1 CHO-K1/Gα15/NPFFR1
                M00431
                NPFFR2 CHO-K1/Gα15/NPFFR2
                M00474
                Opioid & opioid-like receptor OPRD1 CHO-K1/OPRD1/Gα15
                OPRK1 CHO-K1/OPRK1/Gα15
                OPRM1 CHO-K1/OPRM1/Gα15
                OPRL1 CHO-K1/OPRL1/Gα15
                Orexin receptor OX1 CHO-K1/OX1
                OX2 CHO-K1/OX2
                oxoglutarate receptor GPR99 CHO-K1/Ga15/GPR99
                M00483
                P2Y receptor P2Y1 1321N1/P2Y1
                P2Y2 1321N1/P2Y2
                P2Y4 1321N1/P2Y4
                P2Y6 1321N1/P2Y6
                P2Y11 1321N1/P2Y11
                P2Y12 1321N1/P2Y12/Gα15
                Parathyroid hormone receptor PTH1/PTHR1 CHO-K1/PTH1/Gα15
                PTH1/PTHR2 293/PTH2/CRE-Luc
                Peptide P518 receptor QRFP/GPR103 CHO-K1/GPR103/Gα15
                Platelet activating factor receptor PAFR/PTAFR CHO-K1/PTAFR
                Prolactin releasing peptide receptor PRLHR CHO-K1/PRLHR
                Prostanoid receptor DP2 CHO-K1/DP2/Gα15
                EP1/PTGER1 293/EP1
                EP2/PTGER2 CHO-K1/EP2/Gα15
                EP4 293 c18/EP4
                M00485
                FP/PTGFR 293/FP/Gα15
                IP1/PTGIR CHO-K1/IP1/Gα15
                TP/TBXA2R 293/TP
                PTGDR/DP1 CHO-K1/DP1/Gα15
                Proteinase-activated receptor PAR2 CHO-K1/PAR2/Gα15
                PAR4/F2RL3 CHO-K1/PAR4

              返回顶部

                Family
                Receptor
                Cell Line
                Cat.No.
                Somatostatin receptor SST1 CHO-K1/SST1/Gqi5
                SST2/SSTR2 CHO-K1/SST2/Gα15
                SST4/SSTR4 CHO-K1/SST4/Gα15
                SST5/SSTR5 CHO-K1/SST5/Gα15
                Tachykinin receptor NK1/TACR1 CHO-K1/NK1
                NK2/TACR2 CHO-K1/NK2
                NK3/TACR3 CHO-K1/NK3
                Thyrtropin releasing hormone receptor TRH1/TRHR CHO-K1/TRH1
                Urotensin receptor UTR2 CHO-K1/UT2/Gα15
                Vasopressin and oxytocin receptor OT/OXTR CHO-K1/OXTR
                V1B CHO-K1/V1B
                V2 CHO-K1/V2/Gα15
                VIP and PACAP receptor PAC1 CHO-K1/PAC1/Gα15
                VPAC2 CHO-K1/VPAC2/Gα15
                VPAC1/VIP1 CHO-K1/VPAC1/Gα15
                VIPR2 CHO-K1/CRE/Luciferase/VIPR2 New
                Control \ CHO-K1/CRE/Luc
                \ CHO-K1/Gα15
                \ CHO-K1/Gqi5
                \ HEK293/Gα15 New

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